Influence of the immune system on the course of infection with murine coronavirus JHM in suckling mice.
Identifieur interne : 001700 ( Main/Exploration ); précédent : 001699; suivant : 001701Influence of the immune system on the course of infection with murine coronavirus JHM in suckling mice.
Auteurs : K. Pickel ; M A Müller ; V. Ter MeulenSource :
- Advances in experimental medicine and biology [ 0065-2598 ] ; 1981.
Descripteurs français
- KwdFr :
- Animaux, Animaux allaités (immunologie), Facteurs de l'âge, Immunité innée, Immunocompétence, Infections à Coronaviridae (immunologie), Lymphocytes (immunologie), Maladies du système nerveux (immunologie), Rate (cytologie), Souris, Souris de lignée C3H (immunologie), Virus de l'hépatite murine (croissance et développement).
- MESH :
- croissance et développement : Virus de l'hépatite murine.
- cytologie : Rate.
- immunologie : Animaux allaités, Infections à Coronaviridae, Lymphocytes, Maladies du système nerveux, Souris de lignée C3H.
- Animaux, Facteurs de l'âge, Immunité innée, Immunocompétence, Souris.
English descriptors
- KwdEn :
- MESH :
- cytology : Spleen.
- growth & development : Murine hepatitis virus.
- immunology : Animals, Suckling, Coronaviridae Infections, Lymphocytes, Mice, Inbred C3H, Nervous System Diseases.
- Age Factors, Animals, Immunity, Innate, Immunocompetence, Mice.
Abstract
The course of infection with murine corona virus JHM in C3H mice depends on the age of the animals. Mice up to 20 days of age are fully susceptible while mice older than 23 days resist the infection. Protection of suckling mice from death of infection can be provided by intraperitoneal administration of immune spleen cells but not by non-immune spleen cells from adult mice. The immune spleen cells can be generated by priming adult mice, or by priming non-immune spleen cells from adult mice in baby mice with inactivated JHM virus. Thus the immune system might well be involved in the different outcome of infection with JHM-virus in suckling and adult mice, but it does not seem to be the exclusive factor responsible for the achievement of natural resistance.
DOI: 10.1007/978-1-4757-0456-3_31
PubMed: 6278892
Affiliations:
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Le document en format XML
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Ter Meulen</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1981">1981</date><idno type="RBID">pubmed:6278892</idno><idno type="pmid">6278892</idno><idno type="doi">10.1007/978-1-4757-0456-3_31</idno><idno type="wicri:Area/PubMed/Corpus">000755</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000755</idno><idno type="wicri:Area/PubMed/Curation">000755</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000755</idno><idno type="wicri:Area/PubMed/Checkpoint">000745</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000745</idno><idno type="wicri:Area/Ncbi/Merge">000E47</idno><idno type="wicri:Area/Ncbi/Curation">000E47</idno><idno type="wicri:Area/Ncbi/Checkpoint">000E47</idno><idno type="wicri:doubleKey">0065-2598:1981:Pickel K:influence:of:the</idno><idno type="wicri:Area/Main/Merge">001729</idno><idno type="wicri:Area/Main/Curation">001700</idno><idno type="wicri:Area/Main/Exploration">001700</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Influence of the immune system on the course of infection with murine coronavirus JHM in suckling mice.</title><author><name sortKey="Pickel, K" sort="Pickel, K" uniqKey="Pickel K" first="K" last="Pickel">K. Pickel</name></author><author><name sortKey="Muller, M A" sort="Muller, M A" uniqKey="Muller M" first="M A" last="Müller">M A Müller</name></author><author><name sortKey="Ter Meulen, V" sort="Ter Meulen, V" uniqKey="Ter Meulen V" first="V" last="Ter Meulen">V. Ter Meulen</name></author></analytic><series><title level="j">Advances in experimental medicine and biology</title><idno type="ISSN">0065-2598</idno><imprint><date when="1981" type="published">1981</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age Factors</term><term>Animals</term><term>Animals, Suckling (immunology)</term><term>Coronaviridae Infections (immunology)</term><term>Immunity, Innate</term><term>Immunocompetence</term><term>Lymphocytes (immunology)</term><term>Mice</term><term>Mice, Inbred C3H (immunology)</term><term>Murine hepatitis virus (growth & development)</term><term>Nervous System Diseases (immunology)</term><term>Spleen (cytology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Animaux allaités (immunologie)</term><term>Facteurs de l'âge</term><term>Immunité innée</term><term>Immunocompétence</term><term>Infections à Coronaviridae (immunologie)</term><term>Lymphocytes (immunologie)</term><term>Maladies du système nerveux (immunologie)</term><term>Rate (cytologie)</term><term>Souris</term><term>Souris de lignée C3H (immunologie)</term><term>Virus de l'hépatite murine (croissance et développement)</term></keywords><keywords scheme="MESH" qualifier="croissance et développement" xml:lang="fr"><term>Virus de l'hépatite murine</term></keywords><keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Rate</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Spleen</term></keywords><keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Murine hepatitis virus</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Animaux allaités</term><term>Infections à Coronaviridae</term><term>Lymphocytes</term><term>Maladies du système nerveux</term><term>Souris de lignée C3H</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Animals, Suckling</term><term>Coronaviridae Infections</term><term>Lymphocytes</term><term>Mice, Inbred C3H</term><term>Nervous System Diseases</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Age Factors</term><term>Animals</term><term>Immunity, Innate</term><term>Immunocompetence</term><term>Mice</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Facteurs de l'âge</term><term>Immunité innée</term><term>Immunocompétence</term><term>Souris</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The course of infection with murine corona virus JHM in C3H mice depends on the age of the animals. Mice up to 20 days of age are fully susceptible while mice older than 23 days resist the infection. Protection of suckling mice from death of infection can be provided by intraperitoneal administration of immune spleen cells but not by non-immune spleen cells from adult mice. The immune spleen cells can be generated by priming adult mice, or by priming non-immune spleen cells from adult mice in baby mice with inactivated JHM virus. Thus the immune system might well be involved in the different outcome of infection with JHM-virus in suckling and adult mice, but it does not seem to be the exclusive factor responsible for the achievement of natural resistance.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Muller, M A" sort="Muller, M A" uniqKey="Muller M" first="M A" last="Müller">M A Müller</name><name sortKey="Pickel, K" sort="Pickel, K" uniqKey="Pickel K" first="K" last="Pickel">K. Pickel</name><name sortKey="Ter Meulen, V" sort="Ter Meulen, V" uniqKey="Ter Meulen V" first="V" last="Ter Meulen">V. Ter Meulen</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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